So there a great debate out there: which method is faster? Using the mouse or using keyboard shortcuts? I was sure that keyboard would be the fastest but test results are inconclusive [pdf] (some even suggest the complete opposite). One thing that stands out on research is that if one is very proficient with keyboard shortcuts, then those shortcuts (or hot keys) will produce faster work.
Probably belonging to the keyboard camp, the folks at makeawebsitehub shared a set of cheatsheets for many adobe apps. Save, Print, Stick over your monitor and memorize: